The Challenge of Combination Drugs:
Combination drug therapies constitute nearly 15% of the pharmaceutical market. Often discovered in an ad hoc manner, more disciplined methodologies are needed to discover and optimize combination therapies.
The MuSyC Algorithm:
The patented MuSyC (Multi-dimensional Synergy of Combination) algorithm creates a new paradigm in combination drug development. Unlike any other current methods, MuSyC accurately predicts synergy (potency and efficacy) offering greater efficiency in the drug development process.
Scientific References
Charting the Fragmented Landscape of Drug Synergy.
Trends in Pharmacological Sciences 41, 266–280.
Quantifying Drug Combination Synergy along Potency and Efficacy Axes.
Cell Systems 8, 97-108.e16.
MuSyC dosing of adjuvanted cancer vaccines optimizes antitumor responses.
Frontiers in Immunology 13.
Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment.
mBio 14:e02492-23.
Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma.
Cell Reports 39, 110991.
Translatome proteomics identifies autophagy as a resistance mechanism to on-target FLT3 inhibitors in acute myeloid leukemia.
Leukemia 36, 2396–2407 (2022).
Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies.
PNAS 121.
Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence.
iScience 27.
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